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Reducing the ionic strength of a test system increases the rate of antigen-antibody binding in indirect antiglobulin tests. The sensitivity of indirect antiglobulin techniques can also be increased by the use of polyethylene glycol (PEG) as a potentiating medium.
When added to a solution of immuno-reactants, high molecular weight polymers displace other molecules, thereby increasing the amount of contact between antigen and antibody. When PEG is dissolved in a low ionic strength solution, the enhancement properties of both are combined and a smaller volume can be added to each test than if PEG is dissolved in normal ionic strength saline.
Lorne PEG-ADD is a low ionic strength solution contains glycine, a phosphate buffer and polyethylene glycol. The reagent is supplied at optimal dilution for use with all the recommended techniques stated in the pack insert.
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